Enzyme Dynamics from NMR Spectroscopy

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Enzyme Dynamics from NMR Spectroscopy

CONSPECTUS: Biological activities of enzymes, including regulation or coordination of mechanistic stages preceding or following the chemical step, may depend upon kinetic or equilibrium changes in protein conformations. Exchange of more open or flexible conformational states with more closed or constrained states can influence inhibition, allosteric regulation, substrate recognition, formation ...

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ژورنال

عنوان ژورنال: Accounts of Chemical Research

سال: 2015

ISSN: 0001-4842,1520-4898

DOI: 10.1021/ar500340a